The Saints will take on The Reds at Park Hall Stadium with the match due to kick off at 15:00pm.
Last season, Tommy Breslin’s side finished in fifth position in the Danske Bank Premiership.
TNS famously played Cliftonvile in the 2011/2012 UEFA Europa League first qualifying round and progressed after a one all draw was followed by a one nil victory.
Cliftonville are Ireland’s oldest football club and are based in Belfast.
Ticketing information will be released in due course.