Mark Aizlewood’s men met TNS in the Final back in 2013 and were victorious after a dramatic penalty shoot-out at Latham Park.
The ‘Old Gold’ are managed by former Leeds man, Mark Aizelwood and were founded in 1948.
Carmarthen’s record league defeat came at the hands of The Saints when an inspired TNS side won 8-0 back in March 2009.
Carmarthen were the last team to beat TNS at Park Hall Stadium domestically, back in November 2012.
The match will kick off at 20:00pm
You can listen to live commentary of the game on TNS Radio! Click the link www.tnsfc.co.uk and listen to the commentary which will be live from 19:30pm.